Download e-book for iPad: Brain Aging and Therapeutic Interventions by Mahendra K. Thakur, Suresh I.S. Rattan

By Mahendra K. Thakur, Suresh I.S. Rattan

ISBN-10: 9400752369

ISBN-13: 9789400752368

ISBN-10: 9400752377

ISBN-13: 9789400752375

This e-book brings jointly newest info on varied points of mind getting older and at the concepts for intervention and remedy of age-related mind problems. It contains 18 chapters via top researchers, and every bankruptcy is a finished and important evaluation of the subject in query, discusses the present state of affairs and makes a speciality of destiny views. the objective readership is the undergraduate and graduate scholars within the universities, in scientific and nursing schools, in addition to the post-graduate researchers and training clinicians who want to learn about the newest advancements within the box of neurodegenerative issues and their healing interventions. This publication could be of a lot curiosity to pharmaceutical, foodstuff and healthcare for a simple entry to actual and trustworthy info within the box of getting older study and intervention.

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References Alexander P (1967) The role of DNA lesions in the processes leading to aging in mice. Symp Soc Exp Biol 21:29–50 Allinson SL, Dianova II, Dianov GL (2001) DNA polymerase β is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts. EMBO J 20:6919–6926 Almeida KH, Sobol RW (2007) A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst) 6:695–711 Bandyopadhyay U, Das D, Banerjee RK (1999) Reactive oxygen species: Oxidative damage and pathogenesis.

Ionizing radiation can also generate reactive radicals both by direct attack on DNA and by the radiolysis of H2O (Halliwell 1992; Riley 1994; Bandyopadhyay et al. 1999). The range of DNA lesions generated by ROS is extensive and more than 20 products of base oxidation have been identified (Cooke et al. 2003). Modified purine and pyrimidine bases constitute one of the major classes of hydroxyl radical mediated DNA damage together with oligonucleotide strand breaks, DNA-protein crosslinks and abasic (AP) sites (Cadet et al.

In SP-BER, the ligation of the final nick is performed by DNA ligase IIIα (LIGIII α) in association with scaffold protein XRCC1 (Caldecott et al. 1994; Cappelli et al. 1997; Tomkinson et al. 2001). In LP-BER, ligation is performed by DNA ligase I (LIGI) with the physical association with PCNA, which helps to stimulate the effective ligation (Levin et al. 2000; Tom et al. 2001; Tomkinson et al. 2001). , can also be repaired through BER. Sometimes if the break has a 3′-P or 3′-PUA and 5′-OH then the phosphorylation of 5′-OH and removal of phosphate from 3′-end or removal of 3′-PUA becomes necessary before the break is filled up through BER pathway.

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Brain Aging and Therapeutic Interventions by Mahendra K. Thakur, Suresh I.S. Rattan


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