By T. Herdegen, J. Delgado-Garcia
This publication builds a unique bridge from molecular examine to scientific remedy. This strategy finds the useful good points of neurons and glia within the specific context of vulnerability and self-protection, intracellular houses and extracellular matrix. coming up from this platform, this quantity unfolds the molecular and systemic procedures underlying migration problems, axonal damage, fix and regeneration.
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Extra info for Brain damage and repair : from molecular research to clinical therapy
In most cases, several ‘en passant’ presynaptic terminals are formed from axons rather than single boutons terminaux. 11 Synaptic terminals The synaptic terminal is the primary way that information is passed rapidly from neurone to neurone and from neurone to effector organs such as muscle or glands. There are three basic elements to the synapse: a presynaptic terminal containing accumulations of synaptic vesicles and mitochondria, a 20-30 nm wide synaptic cleft (30-50 nm at the myoneural junction), and a postsynaptic membrane that may or may not exhibit specialisations.
Neurosci Biobehav Rev 15: 243-258 Popa-Wagner A, Schröder E, Schmoll H et al (2001) The role of growth-promoting and growth-inhibiting factors in neurorepair after stroke. Effect of age. In: Current Concepts in Experimental Gerontology. C Bertoni-Freddari/H Niedermüller (ed) pp: 177-201 Sapolsky RM (1994) Glucocorticoids, stress and exacerbation of excitotoxic neuron death. Sem Neurosci 6: 323-331 Siesjö BK (1978) Brain energy metabolism. Wiley, Chichester, pp 1-28, pp 151-209 Smith CD, Carney JM, Starke-Reed PE et al (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer’s disease.
Reinberg D. (2002) Review: A unified theory of gene expression. Cell, 108, 439-445. Steward O, Schuman EM. (2001) Protein synthesis at synaptic sites on dendrites. Annual Reviews of Neuroscience 24, 299-325. I. P. JOHNSON University College Medical School, London, UK 3. MORPHOLOGICAL PECULIARITIES OF THE NEURON Summary. This chapter gives an overview of the morphological features of neurones that distinguish them from other cells, allow them to carry out their unique function in the body. After a brief historical review, the peculiar nature of neuronal size and shape are considered, together with the consequences of this for neuronal classification, connectivity, excitability, intracellular transport and vulnerability to injury.
Brain damage and repair : from molecular research to clinical therapy by T. Herdegen, J. Delgado-Garcia